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10.1038/nn.2447 Nat

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Factors that induce the production of advanced glycation end products (AGEs) AGE levels in blood and tissues depend on endogenous sources (chemical reactions) and exogenous sources (diet and smoking)

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The damage caused in the brain by MS is macro-structural (i.e., brain atrophy and volume loss) and microstructural (e.g., disrupted white matter integrity), involving precise areas of the nervous system (Jameen et al., 2019)