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The first significant factor in the pathogenesis of DN is glycemic variability and hyperglycemia

Despite recent advances in decoding overall skin microbiome composition, our understanding of microbial localisation at the niche level is currently limited due to technical constraints

10.1089/ars.2006.8.1693 59 SunK.DAlessandroA.AhmedM

Therapeutic strategies to enhance ICI efficacy via microbiota modulationincluding FMT, probiotics, and engineered microbiomes ( 6.3 Methodology and technology application Intratumoral microbiome research has emerged as a pivotal branch of tumor microenvironment investigation, with current reviews revealing significant technological evolution in detection methodologies

Reimund also proposed that oxidative stress acts as a sleep-inducing factor like the catabolic reaction byproduct adenosine diphosphate