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The National Cancer Institute found that avocados glutathione levels of 19 mg per one-half fruit (2) is several fold higher than that of other fruits, making avocado a powerful antioxidant indeed

& Margantinis, G

It has recently been demonstrated in macrophages that lactate via GPR81/ARRB2 increases acetylation of HMGB1 by inducing nuclear translocation of acetylase p300/CBP resulting in increased endothelium permeability (162)