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To further substantiate this observation and to narrow down the LMP1 sequences that are involved in the direct LMP1-TRAF6 interaction, we tested the ability of purified His-TRAF6 310-522 to interact with immobilized LMP1-derived peptides, which incorporate CTAR1 or CTAR2 sequences (Fig

10.1038/s41419-021-03842-1 276 ZhangY.BaiJ.CuiZ.LiY.GaoQ.MiaoY.et al (2023b)

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Inhibition of IGF-1R signaling is considered a promising strategy for inhibiting tumor growth and improving survival rates in a variety of cancers