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However, there are conflicting reports, as mentioned earlier, that copper is also an essential component of respiratory complex IV, and the amount of copper directly affects the activity of complex IV, thus affecting the overall function of the ETC (3437)

L.Rodrguez-SilvaM.FreyT.GehrmannM.DiazJ

Their core mechanism lies in being bio-reductively activated in specific low-oxygen regions, actively releasing or generating large amounts of ROS for precise killing

Indeed, HPV-positive cervical cancer exhibits distinct metabolic reprogramming, involving increased glycolysis, purine salvage, and glutathione metabolism 8