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By incorporating cells that retain the molecular and functional features of the native tissue, these platforms allow researchers to reproduce patient specific disease mechanisms and treatment responses in vitro

203 In a clinical trial involving 26 men, treatment with an antioxidant cocktail containing both vitamins C and E, as well as coenzyme Q10, was associated with significant improvements in measures of respiratory function in patients with obstructive sleep apnea

However, at the level of whole tumor tissues, it remains difficult to unequivocally attribute heteroplasmy changes to mitochondrial transfer, as clonal expansion [161], therapy-associated selection pressures [80], and stochastic genetic drift [395] can independently remodel mtDNA composition

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