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To systematically evaluate the therapeutic advantages of the dual-protein targeting strategy of Psa-AR through simultaneous degradation of AR and HSP90 in overcoming tumor drug resistance, this study compared the antitumor efficacy of Psa-AR with that of current clinical regimens (including the AR inhibitor enzalutamide, the HSP90 inhibitor pimitespib, and their combination) in 22Rv1 xenograft models (Fig

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