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In addition, LPS and cytokines such as IL-6 and TNF- may induce de novo synthesis of lipids, regulated by sterol regulatory element-binding proteins (SREBP) (227)

On the contrary, mice treated with 3, 5, 50 and 100 nm AuNPs were not affected by the NPs and no adverse effects or death occurred throughout the duration (50 days) of the study [118]

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