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During metastatic evolution, cancer cells exhibit context-dependent metabolic switching, such as the processes of glycolytic metabolism or oxidative phosphorylation of lymph node metastasis or the reliance on fatty acid oxidation to balance the redox of latent brain metastatic cells (183)

FAH vector and siRNA were transfected and MTT assay, apoptosis assay, and sphere formation assay were performed

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In each case, the role of v3 integrin appears to be determined by the guanine nucleotide exchange factors (GEFs) recruited into the integrin signaling complex