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Because it is water-soluble, excess is typically excreted through the kidneys rather than accumulating to toxic levels, making supplementation generally safe even at high therapeutic doses

The relevance of GABAergic inhibitory neurons is furthered by the finding that enrichment of VGF in inhibitory, but not excitatory, neurons is associated with a significant delay in cognitive decline 15

Systemic adverse effects: Contemporary radiology and endocrine reviews catalogue adrenal suppression , hyperglycaemia , hypertension , osteoporosis , skin changes , facial flushing and moreeven after local delivery

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Furthermore, although the introduction of chemiluminescent probes to detect microbial oxygen metabolites allows for rapid estimation of the minimum inhibitory concentration (MIC), this method suffers from poor consistency in detection results [16]