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The readout value of reaction control (0.5% DMSO) was set as a 0% inhibition, and the readout value of background (10 M Positive Control) was set as a 100% inhibition, % Inhibition = 100%-(compound-positive control)/(negative control-positive control)*100%

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3 In the REIMAGINE 1 trial, the most commonly reported adverse events (AEs) were gastrointestinal (GI)-related, occurring in 33/62 (53%) participants in the CagriSema 2.4 mg/2.4 mg group, 28/63 (44%) participants in the CagriSema 1 mg/1 mg group, and 13/64 (20%) participants in the placebo group