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Introduction Cognitive enhancement may be defined as the amplification or extension of core capacities of the mind through improvement or augmentation of internal or external information processing systems ( via physical, behavioral and biochemical activities ( Cognitive enhancer drugs (CEs) are also known as nootropics (from the Greek nous meaning mind and trepein meaning turning/bending), a term initially penned by Corneliu Giurgea when piracetam was found to exhibit memory-enhancing properties in clinical trials ( Cognitive Enhancers, Historical Perspective and State of the Art Historically, CEs have been used to treat conditions related to cognition deficits such as Alzheimers disease, psychiatric disorders such as schizophrenia ( The world of CEs is multifaceted and complex, with different molecules acting with different modes of actions and on different (and often multiple) receptors in the central nervous system (CNS)

It has been shown only the R-form is used by mitochondrial alpha-keto acid dehydrogenases

Endogenous synthesis cannot meet the demand, making them prone to L-carnitine deficiency

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