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You and colleagues leveraged EVs from human dermal fibroblasts (HDFs) to encapsulate mRNA encoding COL1A1

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Because collagen holds together skin, cartilage, and other body structures together, insufficient glycine synthesis is associated with weak muscles and inadequate amounts of protein for maintaining homeostasisclinical studies show that lower plasma glycine levels correlate with lower metabolic capacity

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In line with our findings in FH-deficient cell lines, many of the epithelial cells facing the lumen of the renal cysts showed an intense staining for p21 (Fig