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10.3892/ol.2019.10739 115 ZhangJ

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After 12 weeks, participants in the APCP group exhibited improved skin moisture and texture, and the NMF content of amino acids and total ceramides were significantly increased compared with placebo values

This suggests that a resistance exercise-related mechanism of inducing plasma NO, perhaps due to increased shear stress that triggered an up-regulation in NO-cGMP signaling along with a slow, sustained release of NO from GSH + CIT, may be a conceivable candidate for this response