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Dehydration : Fluid shifts and losses can cause significant dehydration, particularly concerning for elderly patients or those with renal impairment

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In addition, to evaluate the advantages of TAP-VK1 ( 2a ) as the novel compact fluorophore (5 + 5 membered ring), commonly used small molecular fluorophores such as coumarin ( 8 ) (6 + 6 membered ring), NBD ( 9 ) (6 + 5 membered ring), and ABD ( 10 ) (6 + 5 membered ring) were similarly introduced into the thiol group of captopril to give captopril-coumarin ( 8o ), captopril-NBD ( 9o ), and captopril-ABD ( 10o ), respectively (Supplementary Table 4)

The earlier 12-week Phase 2a trial had shown encouraging results (2.6 kg vs 0.8 kg for placebo), but the larger, longer, better-powered trial reversed that finding