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As there is a large heterogeneity in cell loss throughout the brain which is linked to symptomatology (Nana et al., 2014), regions of high cell loss can be compared with regions which are spared or are less affected by the disease process

In drug design, it is used to improve water solubility, serve as a site for PEGylation, or act as a functional handle in pro-drug strategies, allowing for targeted enzymatic release within specific tissues

Treated mice show a 15%20% increase in basal metabolic rate and elevated energy expenditure, with effects positively correlated with NNMT inhibition

Cannabidiol acts at 5-HT(1A) receptors in the human brain: relevance for treating temporal lobe epilepsy

doi: 10.2174/1568026619666191114104718 162 KimBYJangSYChoiDHJungCHMokJOKimCH