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Therefore, these data clearly show the regulatory function of G6PDH during low temperature stress (Lin et al., There are other examples of certain specific NADP-dehydrogenases being regulated at the level of activity and gene expression under diverse stress conditions

In summary, multilayered evidence suggests that increased glutamatergic neurotransmission is present in ALS and might contribute to neurodegeneration (Figure 3)

Recent advances in single-cell and spatial omics have enabled high-resolution dissection of ferroptotic mechanisms in neurodegeneration

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Combating CAR-T cell exhaustion represents a promising therapeutic avenue with broad applicability