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Abbreviations PD: Parkinsons disease DA: Dopaminergic SNc: Substantia nigra pars compacta LBs: Lewy bodies Syn: Synuclein (Protein) LBP: Lewy body pathology CNS: Central nervous system iLBD: Incidental Lewy body disease DMV: Dorsal motor nucleus of the vagus nerve AD: Alzheimers disease LRRK2: Leucine - rich repeat kinase 2 PARK2: Parkinson juvenile disease protein 2 STED: Stimulated emission depletion PINK1: PTEN-induced kinase 1 cPD: Clinical PD pPD: Prodromal PD TH: Tyrosine Hydroxylase SNARE: Soluble N-ethylmaleimide-sensitive-factor attachment receptor SNAP29: Synaptosome Associated Protein 29 TLR-2: Toll-like-Rezeptor 2 Cd68: Cluster of Differentiation ACC: Anterior cingulate cortex PAR2: Protease activated receptor 2 MCM2: Minichromosome maintenance protein 2 HC: Hippocampus LC: Locus caeruleus VMAT2: Vesicular monoamine transporter 2 DJ-1: Protein deglycase 1 Rab38B: Ras-related in brain mTOR: Mammalian Target of Rapamycin eIF2: Elongation initiation factor mtDNA: Mitochondrial DNA GAPDH: Glyceraldehyde dehydrogenase GSH: Glutathion FMRP: Fragile X mental retardation protein RBD: REM sleep behaviour disorder iRBD: Idiopathic RBD DaT: Dopamine Transporter PET: Positron emission tomography TSPO: 18 KDa translocator protein (pre-)LBD: (Pre-)Lewy body disease sNfL: Serum neurofilament light chain DaT: Dopamine Transporter GBA: Glucocerebrosidase SNCA: Alpha-Synculein (Gene) References Berg D, Postuma RB, Bloem B, Chan P, Dubois B, Gasser T, et al

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Theory What determines how a protein moves in an electric field