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Description

R.ShiehY.GulasarianA.OlsonJ.RustandiR

doi: 10.1016/B978-0-12-802168-2.00038-5 173 FloheLGnzlerWASchockHH

In this manuscript, we propose that an integrative neurogenomics workflowcombining multi-omic phenotypeoriented whole-exome sequencing, biologically-oriented common variant burden profiling, biochemical markers, functional metagenomic data, and multidisciplinary clinical interpretationcan generate testable, personalized diagnostic and therapeutic hypotheses in neurodegenerative disorders

CBT, cognitive behavioral therapy

Here we show that SIRT3, a mitochondrial deacetylase highly expressed in HSCs but reduced during aging, suppresses the HSC response to aging that drives maladaptive trained immunity, chronic inflammation and tissue functional decline in mice