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Since these two amino acids are interconverted through a single enzymatic reaction catalyzed by serine hydroxymethyltransferase 16 , increased serine levels may cause elevated glycine levels and vice versa

It plays an important role in energy production, cellular repair, and overall metabolic function

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17 The protein tyrosine phosphatase non-receptor type 22 (PTPN22), which is a lymphoid specific protein tyrosine phosphatase, has also drawn much attention because of polymorphisms associated with ACPA-positive RA with the contribution of PTPN22 to ACPA-positive RA among various ethnicities