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Theoretical Risks and Safety Nuance Preclinical Safety Observations While no major adverse events are reported in the limited human data, researchers note theoretical concerns based on animal models

All efforts were made to minimize the number of animals used

Ferreira N, Goncalves NP, Saraiva MJ, Almeida MR

An assortment of epidemiological and clinical studies have stated glucose and lipid metabolism alterations, insulin resistance, and central obesity as predominant factors for the development of MetS [38, 212]

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