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In addition, when used in combination with DOX at sublethal concentrations, a reduction in IC 50 is observed, representing an increase in the net antitumor activity of the drug (Uruea et al., 2013)

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Yang JH, Wada A, Yoshida K, Miyoshi Y, Sayano T, Esaki K, Kinoshita MO, Tomonaga S, Azuma N, Watanabe M: Brain-specific Phgdh Deletion Reveals a Pivotal Role for L-Serine Biosynthesis in Controlling the Level of D-Serine, an N-methyl-D-aspartate Receptor Co-agonist, in Adult Brain