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Activated mutant FGFR3 (aFGFR3) upregulates the expression of key SSP enzymes such as PHGDH and PSAT1 through downstream signaling pathways, promoting intracellular de novo serine synthesis in bladder cancer cells ( Specifically, elevated serine synthesis subsequently activates the PI3K/Akt pathway in tumor-associated macrophages, shifting macrophages toward an immune-inert phenotype

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