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Dosage Adjustments for Patients with Malabsorption People with conditions like celiac disease or Crohns disease might need more Vitamin B12

However, patients with moderate to severe renal impairment given STIOLTO RESPIMAT should be monitored closely for anticholinergic effects [see Warnings and Precautions (5.10), Use in Specific Populations (8.5, 8.6, 8.7), and Clinical Pharmacology (12.3)]

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However, in the context of elevated vitamin C uptake, high vitamin C can act as a pro-oxidant by reducing iron and promoting lipid peroxidation, GPX4 inactivation, and ferroptotic cell death 125

Travis, H.F., J