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Erastin, a ferroptosis inducer, inhibits the activity of the cystine/glutamate antiporter, blocking the synthesis of glutathione and weakening the cells antioxidant capacity, ultimately leading to ferroptosis

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In the hypoglycemic and hypoxic TME, Teffs suffer from repressed mitochondrial biogenesis, specifically via the loss of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1) [10, 163]

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Some unit cell shrinkage was observed relative to the room-temperature XFEL structure, consistent with these data being collected under cryogenic conditions 7