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Although it is not possible to draw direct comparisons from the real-world evidence study and the RCTs, these examples demonstrate how reporting the treatment effect from different perspectives can provide a broader understanding of the weight loss that can be expected with a medication, and can be useful for clinicians when assessing pharmacotherapeutic options for their patients

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Intervention trials indicate that combined probiotic and prebiotic supplementation can significantly decrease TPOAb and TgAb concentrations, improve gut barrier integrity, and restore microbial diversity in HT patients (Liu et al

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