foxo4-dri senolytic peptide human trial 2024 2025 Molecular modelling of the FOXO4-TP53 interaction to design peptides for the elimination of senescent cancer cells Peptide inhibitors targeting FOXO4-p53 interactions
Peptide inhibitors targeting FOXO4 p53 interactions and inducing senescent cancer cell specific apoptosis bioRxiv The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4 DRI Nature Communications Frontiers Senolytic Peptide FOXO4 DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes CHK2 USP37 axis stabilizes FOXO4 to sustain senescence and evade apoptosis PNAS Targeting Cellular Senescence in Aging and Age Related Diseases: Challenges, Considerations, and the Emerging Role of Senolytic and Senomorphic Therapies
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