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The opioid receptor hypothesis A separate line of work proposed that DSIP possesses agonist activity at opiate receptors a hypothesis explicit in the title of the principal human withdrawal paper, which describes DSIP as a neuropeptide with potential agonistic activity on opiate receptors. [13] Supporting animal evidence came from Scherschlichts group, where DSIP at 25.5 mcg/kg IV attenuated naloxone-precipitated withdrawal jumping in morphine-dependent mice

Frontiers in Cellular and Infection Microbiology , 11, 657775

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(2019) 7-Hydroxymitragynine is an active metabolite of mitragynine and a key mediator of its analgesic effects