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Whole blood was collected from study participants using a 3.2% sodium citrate anticoagulant

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Several methylated pyridines are wellestablished dopaminergic toxins and the NNMT can convert pyridines into toxic compounds (such as 4phenylpyridine into methyl4 phenylpyridinium ion [MPP + ])

Consistent with the enriched molecular functions and biological processes, the KEGG pathway enrichment and GeneMANIA protein relationship analyses indicated that HPL mainly rescued the function of the redox metabolism pathway (glutathione metabolism) that was associated with renal redox function