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This deleterious process is initiated by the activation of CNS-resident microglia, which release an array of cytokines and chemokines, including C-C motif chemokine ligand 2 (CCL2) and C-X-C motif chemokine ligand 10 (CXCL10), that not only amplify local inflammatory responses but, more critically, alter BBB permeability through disruption of tight junction integrity (53, 54)

De nada sirve meter muchos cidos grasos en la mitocondria si luego alli no se tienen recursos para oxidarla

That is their primary therapeutic effect for weight management

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