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Ferroptosis is induced by disruption of glutathione synthesis or inhibition of glutathione peroxidase 4, exacerbated by iron, and prevented by radical scavengers such as ferrostatin-1, liproxstatin-1, and endogenous vitamin E

doi: 10.1016/j.ceca.2024.102854, 35 DengY.YaoY.WangY.YuT.CaiW.ZhouD.et al

Carnitine is essential for the conversion of fat into usable energy, particularly during periods of prolonged exercise or fasting when the body relies more heavily on fat metabolism

Although most irAEs are identified during pre-clinical development, the spectrum, timing and outcomes were only recently investigated through real-world, large-scale pharmacovigilance analyses like the spontaneous reporting systems that looked at the real-time monitoring of these drugs safety profiles [16]