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Notably, these effects were dependent on DAF-16, a FOXO transcription factor regulated by the insulin/IGF-1 signaling (IIS) pathway, suggesting systemic epigenetic control across tissues

Atractylodin attenuates dextran sulfate sodium-induced colitis by alleviating gut microbiota dysbiosis and inhibiting inflammatory response through the MAPK pathway

Once injected, a selective pulse travels through the brain, stimulating the anterior and hypothalamus-pituitary glands

Further research has revealed that KLF2 can bind to the promoter of GPX4 in ccRCC, leading to the downregulation of GPX4 expression, which protects ccRCC cells from ferroptosis, thus promoting tumor cell metastasis (255)

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