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The implantation procedure inevitably disrupts host barriers and alters local immune homeostasis, resulting in a peri-implant microenvironment characterized by excessive inflammation, oxidative stress, and impaired antimicrobial activity of innate immune cells such as neutrophils and macrophages 272

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Fluorescence microscopy images acquired at different magnifi- cations (4, 10, and 20) demonstrated a clear distribution of L929 cells both on the surface and within the porous structure of the GelMA- based hydrogels