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Two topical applications of an unstated amount to the ears of various strains of mice (Swiss, Balb/c, CBA, C5681/6, DBA/2, B6D2F1) produced no significant swelling or other signs (Descotes, 1988)

The metabolite characterization of a new chemical entity (NCE) in various drug discovery stages is crucial in assessment of the safety of a drug for human use

Vitamin B Complex supplements are typically available in tablet, capsule, or liquid form

however, subsequent studies did not confirm this finding and other studies found that the Leu variant was protective rather than disease-associated (see Table 1 and discussion below for details)

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