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Front Cardiovasc Med 2021;8

Conclusion 6-Paradol rescued dopaminergic neurons and improved muscular function against rotenone-induced neurotoxicity, effects that could be attributed to inhibition of neuroinflammatory axis (HMGB-1/TLR4/NFB/TNF-) and suppression of necroptotic signaling cascade (TNFR-1/RIPK1/RIPK3/MLKL), along with enhancement of mitochondrial biogenesis via stimulation of PPAR/PGC1/TFAM axis and attenuation of oxidative stress