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Data availability Boxplot data of differential gene expression in tumor and normal tissues were obtained from TNMplot ( All data are available in the article and the supplementary information, and from the corresponding authors upon reasonable request

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Thus, the heterozygous KEAP1 mutation conferring the growth advantage on cancers is consistent with the two-site binding model and hinge and latch model of the Keap1Nrf2 system

Cancer treatments significantly elevate OS through multiple mechanisms: chemotherapeutic agents, particularly alkylating agents and platinum compounds, generate excessive ROS directly damaging sperm DNA and membranes (87, 88), while radiation therapy induces both acute and chronic OS states in testicular tissue, leading to prolonged spermatogenic dysfunction (95)