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This critical process involves the conjugation of various endogenous molecules (such as glucuronic acid, sulfate, glutathione, or amino acids) to the toxic compounds

Tomasi D, Wang GJ, Volkow ND

From a PPPM perspective, creatine profiling through biofluids, tissue sampling, and advanced imaging (e.g., proton magnetic resonance spectroscopy) offers a minimally invasive approach for early detection, patient stratification, and monitoring of mitochondrial function

doi: 10.1016/j.ejmech.2018.06.053 14 ManachCScalbertAMorandCRmsyCJimnezL

However, secondary preventative interventions such as antiplatelet drugs, -blockers, angiotensin-converting-enzyme (ACE) inhibitors, angiotensin-receptor blockers (ARBs), and HMG-CoA reductase inhibitors (statins) have been shown to significantly reduce CVD risk [3]