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Description

In the synaptic terminals of neurons from the DN of FRDA patients, is observed an increment of the ferroportin levels (Koeppen et al., 2007)

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Dopaminergic neuronal function is typically assessed by performing a dopamine transporter scan (DAT scan), which shows reduced and asymmetric binding in the striatum of patients with idiopathic PD, whereas in individuals with Mn-induced parkinsonism, the DAT scan is mostly normal or reveals a slight decrease in dopamine uptake [56]