NOCs can lead to DNA alkylation, which can induce genetic mutations that ultimately lead to cancer ( 2 S, which can promote the occurrence of CRC by inhibiting butyrate oxidation, destroying the intestinal barrier, and interacting with ROS to induce DNA damage ( Dietary fiber can increase intestinal peristalsis, promote stool excretion, and reduce the food transit time in the colon, thus reducing the contact time of potential carcinogens with intestinal mucosa ( 2.1.2 Familial inheritance Approximately 20-30% of CRC cases are associated with genetic factors, 2-5% of CRC is caused by inherited syndrome, mainly including Lynch syndrome, familial adenomatous polyposis, juvenile polyposis syndrome, MUTYH -associated polyposis, and Peutz-Jeghers syndrome etc ( 2.1.3 Polyps The incidence of CRC is closely related to polyps
In addition, the pathways Lipid and atherosclerosis and Fluid shear stress and atherosclerosis may be involved in lipid metabolic disease
Am J Physiology-Endocrinology Metabolism 257(6):E916E922
Piezoelectric smart biomaterials for bone and cartilage tissue engineering
Bacterial fermentation occurs when dietary fibers enter the colon (45), and as a result, they produce short-chain fatty acids (SCFAs such as acetic acid, propionic acid, and butyric acid) (46), biogenic amines (47), indole and tryptophan derivatives (48), and secondary bile acids, conferring a health benefit