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In AML, where GSH acts as an antioxidant, a decrease in GSH leads to the accumulation of mitochondrial ROS and subsequent apoptosis [58, 59]

In addition, the upregulated mTOR1 pathway due to tuberous sclerosis complex (TSC)2 mutation specifically stimulates the one isoform of PFK in acute myeloid leukemia (AML) (59)

DHODH Dihydroorotate dehydrogenase (DHODH) is a flavin-dependent mitochondrial enzyme that catalyzes the fourth step in the de novo synthesis of pyrimidine nucleotides and is a key enzyme in pyrimidine synthesis

N., Rajagopal, P., Dunyak, B.M., McQuade, T.J., Thompson, A.D., Sunahara, R., Klevit, R.E., Andley, U.P., and Gestwicki, J.E

Furthermore, the production and degradation of ROS are in dynamic equilibrium