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Another mechanism involves effects on neuroendocrine function and the hypothalamic-pituitary-adrenal (HPA) axis, which regulates stress responses

Fortunately, some injections can specifically target chronic pain in painful joints to provide relief, improve mobility, and increase range of motion

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The dosing schedules below mirror the protocols used in published Phase 3 clinical trials and are reported here for educational research context only

This points to at least two mechanisms that are dependent and independent of GrK catalytic activity, respectively