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Abstract Uncontrolled oxidative stress, reported in Salmonella and HIV infections, colorectal cancer or severe acute malnutrition, has been associated with anaerobic gut microbiome alteration, impaired butyrate production, mucosal immunity dysregulation and disruption of host-bacterial mutualism

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From a pharmacokinetic perspective, the herbs bioactive withanolides are metabolized in the liver, and emerging evidence of its hepatotoxic potential adds a critical layer of complexity