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504 Another observational study followed over 7,000 participants who were at least 45 years old at baseline for an average of 16 years

Singh et al., 2006

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In vitro studies using human retinal pigment epithelial (ARPE-19) cells exposed to oxidative (HO) and hyperglycaemic stress demonstrated that the probucolLCA nanoparticles significantly improved cell viability, reduced reactive oxygen species (ROS), restored glutathione (GSH) levels, and enhanced mitochondrial bioenergetics compared with non-functionalized formulations

The Unfolded Protein Responses (UPR) are critical steps in cellular stress and inflammation in patients with NASH [13,109]