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Akt activation plays a pivotal role in mitigating ischemia-reperfusion injury by suppressing apoptotic pathways, enhancing cell survival signals, and promoting Nrf2 nuclear translocation [23]

Phlebotomy encompasses an induction and maintenance phase

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Subcutaneous tirzepatide and oral glutathione do not compete for receptor binding or hepatic metabolism

Due to hemolysis of red blood cells during sample collection, one subject was excluded from all analyses ( N = 12 final subjects)