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TCDD targeted the aryl hydrocarbon receptor in the intermembrane space of organelles in mitochondria (miAhR), leading to degradation of miAhR and dysfunction of mitochondria, which clinically manifested as metabolic dysfunction, e.g

One of the main differences of the aforementioned study and our model is the utilized cell type

Therefore, IGF-1 should not be used alone for GHD screening

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