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In RH13.1, the register of the strand pairing is shifted by a cross-strand hydrogen bond from an aspartic acid sidechain to a backbone amide nitrogen, creating a twisted -sheet cyclized at two ends by a type I turn and an turn, and further stabilized by hydrophobic interactions between the nonpolar sidechains (Fig

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Arachidonic acid directly stimulates ovarian cancer cells, activating the PI3K/AKT pathway and enhancing resistance to platinum-based chemotherapy [139]

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