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The mechanism involves binding of remnants to heparan sulfate proteoglycans (HSPGs) and to members of the LDL receptor family on hepatocytes, followed by endocytosis

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Mller CE, Shi D, Manning M Jr, Daly JW

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Nevertheless, the accumulating evidence situates NRN1 at the intersection of molecular neuroprotection and translational ophthalmology, offering hope for novel strategies to preserve vision in patients at risk of progressive optic neuropathies