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Solasonine also contributed to the ferroptosis of hepatocellular carcinoma cells by the destruction of the glutathione redox system with increasing lipid ROS levels as well as significantly decreasing the levels of GPX4, GSS mRNA, and protein ( TABLE 1 The metabolites from TCM targeting ferroptosis in animal models or cells

Immunology 114 , 246254 (2005)

These findings further underscore the central role of mitochondrial quality control in the multistep evolution of CRC (Fig