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More recent studies, performed by Zouhayr et al., showed many neurological improvements after treatment with hydroxicobalamin (Hdrx) to patients suffering from neurological disorders due to vitamin B12 deficiency (82)

Secondary ischemia impairing the restoration of ion homeostasis following traumatic brain injury

95% confidential interval is shown with 2.5th, 97.5th percentile

We observed that glucose deprivation resulted in a significant decrease in GPx1 protein levels compared with superoxide dismutase (SOD1), whereas the levels of peroxisomal catalase (CAT) and paraoxonase (PON1) were not significantly altered (Supplementary Figure S6)

These are inter-related by the availability of NADPH, a co factor for GSH reductase, which is essential for the maintenance of the redox state of intra mitochondrial GSH