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J Clin Pharm Ther (2020) 45:4360

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on 18 patients with PV (12 males, 6 females) and 18 healthy volunteers found a significant reduction in plasma and RBC GSH-Px and catalase activity and GSH value and increase in plasma MDA level in patients with pemphigus vulgaris.[] ERECTILE DYSFUNCTION The reduced form of glutathione is essential cofactor for NO synthase that catalyzes synthesis of NO from L-arginine in the endothelium

This suppression of CHAC1 by lipids prevented the reduction of GSH and maintained the GSH/GSSG ratio, thereby inhibiting ferroptosis